Objective To investigate the causes and preventive measures of misdiagnosis of intraosseous gout nodules as endochondroma.Methods The clinical data of 1 patient with misdiagnosed intraosseous gout nodule admitted in 2022 were retrospectively analyzed.Results This case was admitted to hospital due to pain at great toe of his right foot for 1 week.After imaging examination,it was misdiagnosed as endochondroma.Tumor curettage and bone graft were proposed,and postopera-tive pathology indicated that it was consistent with gout nodule.The diagnosis was intraosseous gout nodule,and the misdiag-nosis lasted 7 d.After diagnosis,Febuxostat was administered to reduce uric acid levels,and the incision healed well before discharge.At 1-year follow-up after surgery,the patient had no special discomfort but normal activity at right great toe.Conclusion Intraosseous gout nodule is relatively rare,and imaging manifestation are similar to enchondroma,which may lead to misdiagnosis.Clinicians should strengthen the understanding of the disease,and for patients with elevated uric acid,the possibility of gout should be considered.The relevant examination should be performed in time to avoid misdiagnosis.