Objective To analyze characteristics of CT images of brain metastases and causes of misdiagnosis.Methods CT imaging data and clinical data of 3 patients with misdiagnosed brain metastases admitted from 2020 to 2022 were retrospectively analyzed.Results A patient presented with headache,and CT showed a nodular enhancement lesion on the left frontal lobe.Meningioma was preliminarily diagnosed,and the postoperative pathological results showed breast cancer brain metastases.A patient presented with fever and headache.CT showed a low-density area in the right parietal lobe with annular enhancement around it.A preliminary diagnosis of brain abscess was made,and anti-infective treatment for 1 week failed.Bronchoscopy and pathological examination confirmed the diagnosis of lung adenocarcinoma.Combined with head mag-netic resonance imaging and whole-body CT examination results,it was diagnosed as a lung cancer brain metastasis.A patient presented with sudden limb weakness.CT showed low density shadow in the right basal ganglia,and cerebral infarction was initially diagnosed.After 5 d of ineffective treatment and worsening symptoms,reexamination with magnetic resonance imaging confirmed the diagnosis of colorectal cancer brain metastasis.The misdiagnosis lasted 10-18 d.After diagnosis,3 patients re-ceived whole brain radiotherapy and targeted drug therapy or chemotherapy,and symptoms of the patients were relieved or dis-appeared.At 1-year follow-up,no new metastases were found.Conclusion The CT imaging characteristics of brain metasta-ses are varied,which can easily be confused with other intracranial lesions,leading to misdiagnosis.It is necessary to collect the history in detail,combine multi-modal imaging examination and improve the doctor's alertness,to reduce the misdiagnosis.