摘要
目的 探讨那不勒斯预后评分(NPS)对青年肺腺癌患者的预后预测价值.方法 回顾性分析 2017 年11 月至2022 年12 月收治的青年肺腺癌患者110 例的临床资料,根据NPS分为低危组(0 分)27 例、中危组(1～2 分)58 例和高危组(3～4 分)25 例,比较3 组患者临床资料.采用Kaplan-Meier和Cox回归分析评估NPS对预后的影响.结果 3 组TNM分期、乳酸脱氢酶、SII、癌胚抗原水平及手术、化疗、靶向治疗患者所占比例比较差异有统计学意义(P<0.05,P<0.01);年龄、性别、吸烟史、婚姻状态、体质量指数、血小板/淋巴细胞比率、神经元特异性烯醇化酶比较差异无统计学意义(P>0.05).Kaplan-Meier生存分析曲线显示高危组患者总生存期和无进展生存期明显短于低危组和中危组(P<0.01).TNM分期、手术、化疗和NPS分级是影响青年肺腺癌患者总生存期的独立影响因素(P<0.05,P<0.01).结论 NPS对青年肺腺癌患者的预后有良好预测价值.
Abstract
Objective To evaluate the prognostic value of Naples prognostic score(NPS)in young patients with lung adenocarcinoma.Methods The clinical data of 110 young patients with lung adenocarcinoma admitted from November 2017 to December 2022 were retrospectively analyzed.According to NPS,they were divided into low-risk group(0 point,n=27),moderate-risk group(1-2 points,n=58)and high-risk group(3-4 points,n=25).The clinical data of the three groups were compared.Kaplan-Meier and Cox regression analyses were used to evaluate the effect of NPS on prognosis.Results There were significant differences in the proportion of patients with TNM stage,lactate dehydrogenase,SII,carcinoembryonic antigen level,surgery,chemotherapy and targeted therapy among the three groups(P<0.05,P<0.01).There were no significant differences in age,sex,smoking history,marital status,body mass index,platelet/lymphocyte ratio and neuron-specific eno-lase(P>0.05).Kaplan-Meier survival analysis curve showed that the overall survival and progression-free survival of high-risk group were significantly shorter than those of low-risk and moderate-risk groups(P<0.01).TNM stage,surgery,chemo-therapy and NPS staging were independent factors affecting the OS of young lung adenocarcinoma patients(P<0.05,P<0.01).Conclusion NPS has good prognostic value in young patients with lung adenocarcinoma.
基金项目
河北省自然科学基金资助项目(H2021307017)
河北省重点研发项目(21377795D)
维普
万方数据