Observation on the Efficacy of Qiju Dihuang Pills Combined with Meibo-mian Gland Massage and Compression in the Treatment of Dry Eye Syn-drome Caused by Meibomian Gland Dysfunction
Observation on the Efficacy of Qiju Dihuang Pills Combined with Meibo-mian Gland Massage and Compression in the Treatment of Dry Eye Syn-drome Caused by Meibomian Gland Dysfunction
Objective To investigate the efficacy of Qiju Dihuang pills combined with meibomian gland massage and compression in the treatment of dry eye syndrome caused by meibomian gland dysfunction(MGD),as well as their impact on subjective symptoms,inflammatory factors in tears,and quality of life.Methods Eighty-four patients with dry eye syndrome caused by MGD from January 2022 to July 2023 were selected and randomly divided into the observation group(n=42)and the control group(n=42).Both groups received conventional treatment.In addition,the control group received combined meibomian gland massage,while the observation group received Qiju Dihuang pills on the basis of the control group's treat-ment.The course of treatment was 8 weeks for both groups.The clinical efficacy of the two groups was compared,as well as the pre-and post-treatment scores for subjective symptoms,meibomian opening status,meibomian gland secretion characteris-tics,Schirmer I test(SIT),corneal fluorescence staining(FLS),tear film breakup time(TBUT),tear interleukin-10(IL-10),tear interleukin-13(IL-13),fibroblast growth factor receptor 2(FGFR2)expression level and quality of life.The inci-dence of adverse reactions was recorded for both groups.Results Both groups had 2 dropouts.The total effective rate of treatment in the observation group[90.00％(36/40)]was higher than that in the control group[72.50％(29/40)],show-ing significant differences(P<0.05).At 4 and8 weeks after treatment,the SIT and tear film breakup time in the observation group were longer than those in the control group,while the subjective symptom scores,meibomian gland function scores,and FLS were lower than those in the control group(P<0.01).At 4 and 8 weeks after treatment,the expression levels of IL-10 and FGFR2 in tears in the observation group were higher than those in the control group,while the expression level of IL-13 was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).At 8 and 12 weeks after treatment,the scores of the quality of life scale brief in the ob-servation group were higher than those in the control group(P<0.05).Conclusion The combination of Qiju Dihuang pills and meibomian gland massage and compression is safe and effective in the treatment of dry eye syndrome caused by MGD,which can inhibit inflammatory reactions,alleviate clinical symptoms,and enhance patients'quality of life.
维普
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