Objective To explore the causes and preventive measures of misdiagnosis of intussusception in children.Methods The clinical data of 3 children with intussusception treated from March 2021 to March 2024 were retrospectively an-alyzed.Results In this group,1 patient with vomiting,1 patient with abdominal pain and excretion of mucous blood stool and 1 patient with diarrhea were misdiagnosed with gastritis,enteritis and bacillary dysentery,respectively,which did not re-spond well to symptomatic treatment.All 3 patients were confirmed with intussusception by abdominal ultrasonography.The duration of misdiagnosis was 2-4 d.After diagnosis,2 patients were discharged from hospital after enema reduction and surgi-cal treatment,and no recurrence was observed at 3-month follow-up.The other patient was transferred to a superior hospital for partial resection and anastomosis,and was discharged after recovery.Conclusion Intussusception has no typical symp-toms in the early stage,which is prone to misdiagnosis.The diagnosis should be combined with the symptoms,medical histo-ry,physical examination,abdominal X-ray and ultrasound,which is helpful to reduce misdiagnosis.