Objective To investigate the diagnostic value of urinary kidney injury molecular-1(KIM-1),triglycer-ide/cystatin C(TG/Cys C)and urinary microalbumin/creatinine ratio(ACR)in diabetic patients with early kidney injury,so as to provide reference for avoiding clinical delay in diagnosis.Methods In total,200 diabetic patients with early kidney injury admitted from January 2020 to December 2023 were selected as kidney injury group,and 50 diabetic patients without kidney injury were selected as control group according to the 4∶1 matching principle.The general data,urinary KIM-1,TG/Cys C and urinary ACR of the two groups were analyzed,and the correlation between urinary KIM-1,TG/Cys C and urinary ACR in the renal injury group was analyzed.Multivariate logistic regression analysis was conducted to analyze the effects of urinary KIM-1 and TG/Cys C on the early renal injury of diabetic patients,and to analyze the diagnostic value of urinary KIM-1,TG/Cys C and urinary ACR in the early renal injury of diabetic patients.Results The proportion of hypertensive pa-tients and HBA1c in renal injury group were higher than those in control group,and the disease course was longer than that in control group(P＜0.05,P＜0.01).Urine KIM-1 and urinary ACR in renal injury group were higher than those in control group,while TG/Cys C was lower than that in control group(P＜0.01).Urinary KIM-1 was positively correlated with urinary ACR in renal injury group(r=0.749,P＜0.001),while TG/Cys C was negatively correlated with urinary ACR(r=-0.693,P＜0.001).Urinary KIM-1 and TG/Cys C were independent influencing factors of early renal injury in diabetic patients(P＜0.01).The area under the curve of the combination of KIM-1+TG/Cys C and urinary ACR in the diagnosis of early kidney in-jury in diabetic patients was greater than that of urinary KIM-1+TG/Cys C,urinary KIM-1+urinary ACR,TG/Cys C+urina-ry ACR.Conclusion Urinary KIM-1,TG/Cys C are closely related to urinary ACR in diabetic patients with early kidney inju-ry,and the combined detection can significantly improve the diagnostic efficiency of early kidney injury in diabetic patients.
维普
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