Objective To investigate the clinical effect of Anisodamine Hydrobromide tablets and Prostaglandin Sodi-um tablets in the treatment of ischemic diabetic foot,and to analyze the safety of drug use.Methods A total of 93 patients with ischemic diabetic foot admitted from August 2020 to October 2021 were selected and divided into observation group(n=47)and control group(n=46)according to treatment methods.The control group was given Prostaglandin Sodium tablets on the basis of conventional treatment,and the observation group was given Anisodamine Hydrobromide tablets on the basis of conventional treatment.The clinical efficacy,internal diameter and blood flow velocity of dorsal foot artery,time of new granu-lation and healing of wound were compared,and hepatic and renal function indexes and blood glucose related indexes were de-tected between the two groups.Results The total effective rate of observation group[95.74%(45/47)]was higher than that of control group[86.96%(40/46)],suggesting significant difference(P＜0.05).There was no significant difference in the diameter of dorsal foot artery between the two groups after treatment(P＞0.05),but the blood flow velocity of dorsal foot ar-tery in the observation group was higher than that in the control group(P＜0.05).The time of new granulation and healing of wound in observation group was shorter than that in control group(P＜0.05).There were no significant differences in aspar-tate transaminase,alanine aminotransferase and serum creatinine between the two groups before and after treatment(P＞0.05).The levels of blood glucose-related indexes in the two groups after treatment were lower than those before treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Conventional treatment combined with Anisodamine Hydrobromide tablets in the treatment of ischemic diabetic feet has better clinical efficacy,without increasing adverse reactions,and has better safety of clinical drug use.
维普
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