Objective To investigate the clinical significance of regional cerebral oxygen saturation(rSO2)monito-ring combined with amplitude-integrated electroencephalography(aEEG)in predicting neurobehavioral development of brain injury in premature infants(BIPI),so as to take corresponding measures early and improve the prognosis of pediatric patients.Methods In total,116 patients with BIPI treated from February 2022 to February 2023 were selected as observation group and non-BIPI as control group.aEEG and rSO2 examinations were performed.The aEEG score and rSO2 of the two groups were compared,and the aEEG score and rSO2 of the children with different gestational age,degree of brain injury and neu-robehavioral development in the observation group were compared.The correlation between the total score of aEEG,rSO2 and gestational age,neurobehavioral development and degree of brain injury was analyzed,and the predictive value of the total score of aEEG and rSO2 on neurobehavioral development abnormalities of BIPI was analyzed.Results Continuity,sleep-wake cycle,lower boundary amplitude,bandwidth and lower boundary value,total score of aEEG and rSO2 in observation group were lower than those in control group(P＜0.01).There were significant differences in gestational age,brain injury degree,continuity of neurobehavioral development,sleep-wake cycle,lower boundary amplitude,bandwidth and lower boundary val-ue,total score of aEEG and rSO2 in the observation group(P＜0.05,P＜0.01).Spearman correlation analysis showed that the total aEEG score and rSO2 were positively correlated with gestational age(r=0.654,0.678,P＜0.01),and negatively correlated with the degree of brain injury and neurobehavioral development(r=-0.642,-0.747,P＜0.01;r=-0.687,-0.659,P＜0.01).The area under the curve(AUC)of aEEG score,rSO2 alone and in combination for the prediction of neurobehavioral abnormalities in BIPI were 0.813,0.810 and 0.909,respectively.The AUC of combined prediction was sig-nificantly larger than that of single prediction,guide clinical intervention measures in early stage,and prevent or reduce the occurrence of sequelae.Conclusion Low aEEG score and rSO2 are associated with gestational age,neurobehavioral develop-ment and brain injury degree of BIPI.The combination of aEEG score and rSO2 has a high value in predicting neurobehavioral development abnormalities of BIPI.
维普
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