Objective To summarize the etiology and prognosis and outcome of 75 preterm infants of different gesta-tional ages,so as to improve the quality of life of preterm infants.Methods Seventy-five preterm infants born from January 2012 to February 2022 were retrospectively selected and divided into early group(28-<34 weeks,n=21)and advanced group(34-<37 weeks,n=54)according to gestational age.The causes of preterm birth and complications of premature in-fants of different gestational ages,and complications of premature infants with different birth weight were analyzed.Results In the early group,the main causes were preterm premature rupture of membrane(PPROM)[42.86%(9/21)]and hyper-tension during pregnancy[14.29%(3/21)].In the advanced group,the main causes were PPROM[37.04%(20/54)],scarred uterus[16.67%(9/54)],and placental abruption/previa[11.11%(6/54)].The incidence of neonatal respirato-ry distress syndrome(NRDS),intracranial hemorrhage,hyperbilirubinemia,scleredema,apnea,respiratory failure,asphyxia and pneumonia in early group was higher than that in advanced group(P<0.05,P<0.01).The incidence of coagulation dysfunction,sepsis,hypoxic-ischemic encephalopathy,NRDS,intracranial hemorrhage,hyperbilirubinemia,scleredema,ap-nea and respiratory failure in preterm infants with birth weight<1 500 g was higher than that in preterm infants with birth weight 1 500-<2 500 g(P<0.05,P<0.01).Conclusion The causes of preterm birth in preterm infants of different ges-tational ages vary.The smaller the gestational age and the lower the birth weight,the higher the risk of complications of pre-term infants.Early identification of the causes of preterm birth and timely implementation of corresponding prevention and treatment measures should be carried out in clinical practice to prolong gestational age,reduce complications,and improve clinical outcomes.