Objective To investigate the effect of application of Qingre Xiaoyong Zhitong prescription combined with photon therapy on the incidence of infection and wound healing after cesarean section(C-section),and to analyze its safety.Methods A total of 150 patients who underwent C-section from January 2022 to July 2023 were selected and divided into ap-plication group(n=50),photon therapy group(n=50)and combination group(n=50)by random number table method.The application group was treated with Qingre Xiaoyong Zhitong prescription,the photon therapy group was treated with photon therapy,and the combination group was treated with Qingre Xiaoyong Zhitong prescription combined with photon therapy.Postoperative infection,postoperative rehabilitation,postoperative incision healing effect,local microcirculation index,serum inflammatory factor levels[hypersensitive C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),white blood cell(WBC)count]and incision pain score of the three groups were compared.The incidence of adverse reactions in the three groups were recorded.Results There was no significant difference in the incidence of superficial abdominal incision infection and fever among the three groups(P>0.05).The wound healing time,time of off-bed activity and length of hospitalization in combination group were shorter than those in application group and photon therapy group,and the rate of good wound healing was higher than that in application group and photon group(P<0.05).At 3 d after operation,the local capillary diameter and blood flow velocity in combination group were higher than those in application group and photon therapy group(P<0.05).At 1 and 3 d after operation,hs-CRP,TNF-α and WBC counts in the combination group were lower than those in the application group and the photon therapy group(P<0.05).Incision pain scores of combination group were lower than those of application group and photon therapy group at 12 h,24 h,2 d and 3 d after operation(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P<0.05).Conclusion The combination of Qingre Xiaoyong Zhitong prescription and photon therapy has a good effect on preventing postoperative infection after cesarean section,and does not increase adverse reactions,with good safety.