血清成纤维细胞生长因子1和壳多糖酶3样蛋白1水平与糖尿病合并骨质疏松患者骨代谢的关系

Relationship of Serum Levels of Fibroblast Growth Factor 1 and Chitosi-nase 3-like Protein-1 with Bone Metabolism in Diabetic Patients with Osteo-porosis

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中文摘要：目的探讨血清成纤维细胞生长因子1(FGF1)、壳多糖酶3 样蛋白1(Chi3L1)水平与糖尿病合并骨质疏松患者骨代谢的关系.方法选取2021 年3 月至2024 年3 月收治的糖尿病合并骨质疏松患者80 例,纳入骨质疏松组;另选同期就诊的50 例单纯糖尿病患者,纳入对照组.比较 2 组FGF1、Chi3L1、骨代谢及糖脂代谢指标水平;Pearson系数分析血清FGF1、Chi3L1 与糖尿病合并骨质疏松患者骨代谢的相关性;多因素logistic回归分析糖尿病患者发生骨质疏松的影响因素;受试者工作特征曲线分析血清FGF1、Chi3L1 对糖尿病患者发生骨质疏松的诊断价值.结果骨质疏松组FGF1、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、甲状旁腺激素(PTH)、糖化血红蛋白高于对照组,Chi3L1、总Ⅰ型胶原氨基端前肽(T-PⅠNP)、25-羟维生素D(25-OH-D)、骨钙素(OCN)低于对照组(P＜0.01).糖尿病合并骨质疏松患者血清FGF1 与β-CTX、PTH呈正相关,与T-PⅠNP、25-OH-D、OCN呈负相关(P＜0.01);而血清Chi3L1 与β-CTX、PTH呈负相关,与T-PⅠNP、25-OH-D、OCN呈正相关(P＜0.01).FGF1、Chi3L1、T-PⅠNP、25-OH-D、β-CTX、PTH、OCN是糖尿病患者发生骨质疏松的危险因素(P＜0.01).血清FGF1、Chi3L1 诊断糖尿病患者发生骨质疏松的曲线下面积分别为0.925、0.803.结论糖尿病合并骨质疏松患者血清FGF1、Chi3L1 水平存在异常,且与患者骨代谢具有显著相关性.

外文摘要：Objective To investigate the relationship between serum levels of fibroblast growth factor 1(FGF1),ch-itosinase 3-like protein-1(Chi3L1)and bone metabolism in diabetic patients with osteoporosis.Methods A total of 80 pa-tients with diabetes mellitus combined with osteoporosis admitted from March 2021 to March 2024 were included in the osteo-porosis group.Another 50 patients with simple diabetes were selected and included in the control group.The levels of FGF1,Chi3L1,bone metabolism and glycolipid metabolism were compared between the two groups.Pearson coefficient was used to analyze the correlation between serum FGF1,Chi3L1 and bone metabolism in diabetic patients with osteoporosis.Multivariate logistic regression was used to analyze the influencing factors of osteoporosis in diabetic patients.The diagnostic value of serum FGF1 and Chi3L1 for osteoporosis in diabetic patients was analyzed by receiver operating characteristic(ROC)curve.Results FGF1,type Ⅰ collagen carboxy-terminal peptide β special sequence(β-CTX),parathyroid hormone(PTH)and glycosy-lated hemoglobin in osteoporosis group were higher than those in control group,while Chi3L1,total type Ⅰ collagen amino terminal propeptide(T-PⅠNP),25-hydroxyvitamin D(25-OH-D)and osteocalcin(OCN)were lower than those in control group(P＜0.01).In diabetic patients with osteoporosis,serum FGF1 was positively correlated with β-CTX and PTH,and negatively correlated with T-PⅠNP,25-OH-D and OCN(P＜0.01).Serum Chi3L1 was negatively correlated with β-CTX and PTH,but positively correlated with T-PⅠNP,25-OH-D and OCN(P＜0.01).FGF1,Chi3L1,T-PⅠNP,25-OH-D,β-CTX,PTH,and OCN were the risk factors for osteoporosis in diabetic patients(P＜0.01).The area under the ROC curve of serum FGF1 and Chi3L1 in the diagnosis of osteoporosis was 0.925 and 0.803,respectively.Conclusion The levels of serum FGF1 and Chi3L1 were abnormal in patients with diabetes complicated with osteoporosis,and were significantly correla-ted with bone metabolism.

外文关键词：

Diabetes mellitusOsteoporosisBone metabolismFibroblast growth factor 1Chitinase 3-like protein 1CorrelationRisk factorsDiagnosis

作者：

吴晓丽、陈大双、李琪琪、李上达

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作者单位：

621000 四川绵阳,绵阳市中医医院内分泌科

关键词：

糖尿病骨质疏松骨代谢成纤维细胞生长因子1 壳多糖酶3样蛋白1 相关性危险因素诊断

出版年：

2025

DOI：