Objective To explore the clinical effect of Huatan Quyu decoction assisting Western medicine in the treatment of stable angina pectoris(SAP)and its impact on the signal transduction pathway of phosphatidylinositol 3-kinase(PI3K)/serine-threonine kinase(Akt).Methods A total of 100 patients with SAP(phlegm and blood stasis syndrome)treated from July 2021 to July 2023 were selected and divided into control group(n=50)and research group(n=50)by random number table method.The control group was treated with conventional Western medicine,and the research group was treated with Huatan Quyu decoction assisting conventional Western medicine.The therapeutic effect,traditional Chinese medi-cine(TCM)syndrome score,lipid level,PI3K/Akt signal transduction pathway factor,Seattle Angina Questionnaire(SAQ)score before and after treatment,and the occurrence of adverse reactions during treatment were compared between the two groups.Results The therapeutic effect of angina pectoris and the total effective rate of TCM in the research group were higher than those in the control group(P＜0.05).After treatment,the research group was lower than the control group(P＜0.05)with respect to chest tightness,shortness of breath,chest pain,palpitation,sputum output,tongue purpleness and pulse score(P＜0.05).After treatment,the levels of low-density lipoprotein cholesterol(LDL-C),triglyceride and total cholesterol in peripheral blood of the research group were lower than those of the control group,while the levels of high-density lipoprotein cholesterol(HDL-C)was higher than that of the control group(P＜0.05).After treatment,the levels of PI3K and Akt in the research group were lower than those in the control group,while the levels of phosphorylated Akt were higher than those in the control group(P＜0.05).The SAQ score of the research group was higher than that of the control group(P＜0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions between the research group[8.00%(4/50)]and the control group[12.00%(6/50)](P＞0.05).Conclusion Huatan Quyu decoction can improve the condition of SAP patients by inhibiting PI3K/Akt signal transduction pathway,and can significantly improve the therapeu-tic effect.
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