Effects of Shenqi Tangshen Prescription on Clinical Efficacy and Serum Re-nal Fibrosis Markers in Patients with Diabetic Kidney Disease with Qi-Yin Deficiency Syndrome
Objective To investigate the effect of Shenqi Tangshen prescription on diabetic kidney disease(DKD)with Qi-Yin deficiency syndrome.Methods Fifty-eight DKD patients with Qi-Yin deficiency syndrome treated from June 2021 to June 2024 were selected and divided into observation group(n=29)and control group(n=29)according to random number table method.The observation group was treated with conventional treatment combined with Shenqi Tangshen prescrip-tion,and the control group was treated with conventional treatment.Clinical efficacy,glucose metabolism indexes,renal func-tion indexes and serum renal fibrosis markers were compared between the two groups.Results The total effective rate of ob-servation group was higher than that of control group(P＜0.05).After treatment,fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in observation group were lower than those in control group(P＜0.05).After treatment,the estimated glomerular filtration rate of observation group was higher than that of control group,whereas the urina-ry albumin-to-creatinine ratio was lower than that of control group(P＜0.05).After treatment,the serum transforming growth factor β1 and connective tissue growth factor in the observation group were lower than those in the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Shenqi Tangshen prescription for DKD patients with Qi-Yin deficiency syndrome can improve glucose metabolism and renal function,and has advantages in improving serum renal fibrosis markers and renal microvascular lesions,with good safety and significant clinical efficacy.
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