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儿童咳嗽变异性哮喘临床误诊分析

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目的 分析儿童咳嗽变异性哮喘的临床误诊原因.方法 回顾分析2023 年1 月至2024 年1 月收治的儿童咳嗽变异性哮喘误诊5 例病例资料.结果 5 例患儿以慢性咳嗽为主要或唯一症状就诊,主要表现为刺激性干咳3 例,病程中有间断发热、鼻塞、流涕等类上呼吸道感染样症状2 例;肺部听诊呼吸音粗糙3 例,痰鸣音1 例;5 例行结核菌素纯蛋白衍生物试验,4 例阴性、1 例阳性;4 例行胸部X线检查示肺纹理增粗,1 例行鼻窦X线检查示鼻窦腔密度增高.2 例误诊支气管肺炎、2 例误诊上呼吸道感染、1 例误诊慢性鼻窦炎,给予针对性治疗后效果不佳,后行支气管舒张试验均阳性,3 例皮肤变应原试验阳性,5 例肺功能检查异常.结合病史、症状及辅助检查结果均确诊为儿童咳嗽变异性哮喘.误诊时间1~7 个月.确诊后5 例均予沙丁胺醇联合布地奈德雾化混悬液雾化吸入,1 例每晚服用孟鲁司特钠咀嚼片治疗,治疗1~4 周咳嗽得到控制.随访6 个月未见复发.结论 儿童咳嗽变异性哮喘早期表现无特异性,误诊率较高;对于慢性咳嗽反复发作、咳嗽迁延不愈的患儿应警惕儿童咳嗽变异性哮喘可能,应严格按照诊疗指南诊断,仔细询问病史,及时行特异性检查,以提高早期诊断率,降低误诊率.
Clinical Misdiagnosis of Cough Variant Asthma in Children
Objective To analyze the causes of clinical misdiagnosis of cough variant asthma(CVA)in children.Methods The case data of 5 children with misdiagnosed CVA admitted from January 2023 to January 2024 were retrospec-tively analyzed.Results Chronic cough was the main or the only symptom in 5 patients,and irritant dry cough was the main manifestation in 3 patients.There were intermittent fever,nasal congestion,runny nose and other upper respiratory tract infection-like symptoms in 2 patients.Pulmonary auscultation revealed rough breathing sound in 3 patients,and coarse rales in 1 patient.Of 5 patients receiving tests of pure protein derivatives of tuberculin,4 patients were negative and 1 patient was pos-itive.Chest X-ray examination showed thickening and disordered lung texture in 4 patients,and sinus X-ray examination showed increased density in the sinus cavity in 1 patient.Two patients were misdiagnosed with bronchopneumonia,2 patients with upper respiratory tract infection,and 1 patient with chronic sinusitis.After targeted treatment,the effect was not favora-ble.The bronchial dilation test was positive in all patients,the skin allergen test was positive in 3 patients,and the pulmonary function test was abnormal in 5 patients.Combined with the history,symptoms and auxiliary examination results,the diagnosis was CVA in children.Misdiagnosis lasted from 1 to 7 months.After diagnosis,all 5 patients were treated with aerosol inhala-tion of Salbutamol combined with aerosol inhalation of Budesonide suspension,and 1 patient was treated with Montelukast So-dium chewable tablets every night.At 1 to 2 weeks after treatment,the cough was controlled and the pulmonary function was improved or recovered.No recurrence was found at 6-month follow-up.Conclusion The early symptoms of CVA in children are nonspecific and the misdiagnosis rate is high.For children with recurrent chronic cough and persistent cough,doctors should be alert to the possibility of CVA in children,make diagnosis in strict accordance with the diagnosis and treatment guidelines,carefully inquire about the medical history,and perform specific examinations in time to improve the early diagno-sis rate and reduce the misdiagnosis rate.

Asthma,cough variabilityChildrenBronchopneumoniaUpper respiratory tract infectionChronic si-nusitisMisdiagnosisDiagnosisDifferential diagnosis

戴丽娟、李乐

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211100 南京,南京市江宁医院儿科

哮喘,咳嗽变异性 儿童 误诊 支气管肺炎 上呼吸道感染 慢性鼻窦炎 诊断 鉴别诊断

2025

临床误诊误治
解放军白求恩国际和平医院

临床误诊误治

影响因子:0.914
ISSN:1002-3429
年,卷(期):2025.38(2)