摘要
目的 探讨柴芍承气汤保留灌肠联合九合丹外敷治疗肝胃实热证急性胰腺炎的效果.方法 纳入2021 年7 月至 2022 年 9 月收治的 60 例肝胃实热证急性胰腺炎患者,采用随机数字表法分为观察组和对照组各30 例,对照组给予常规西药联合九合丹外敷治疗,观察组在对照组基础上联合柴芍承气汤保留灌肠治疗,均治疗7d.治疗后比较2 组临床疗效,腹胀及腹痛缓解时间、进食时间、首次排便时间、肠鸣音恢复时间与住院时间;比较2 组治疗前后中医证候积分及C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血淀粉酶水平,以及2 组不良反应发生情况.结果 观察组总有效率为93.33%高于对照组的 73.33%(P＜0.05).观察组治疗后腹胀及腹痛缓解时间、进食时间、首次排便时间、肠鸣音恢复时间与住院时间均短于对照组(P＜0.01).治疗后2 组脘腹胀痛、大便黏滞不通、发热、胸闷不舒、烦渴引饮中医证候积分均下降,且观察组低于对照组(P＜0.05).治疗后 2 组CRP、IL-6、TNF-α、血淀粉酶均下降,且观察组低于对照组(P＜0.05,P＜0.01).2 组不良反应发生率比较差异无统计学意义(P＞0.05).结论 柴芍承气汤保留灌肠联合九合丹外敷治疗肝胃实热证急性胰腺炎患者的效果良好,可有效减轻患者症状、促进胃肠功能恢复,降低炎性因子及血淀粉酶水平,且安全性较好.
Abstract
Objective To explore the effect of retention enema with Chaishao Chengqi decoction combined with exter-nal application of Jiuhedan on acute pancreatitis with excess heat syndrome of liver and stomach.Methods A total of 60 pa-tients with acute pancreatitis and excess heat syndrome of liver and stomach treated from July 2021 to September 2022 were in-cluded and divided into the observation group(n=30)and the control group(n=30)by random number table method.The control group was given conventional Western medicine combined with external application of Jiuhedan,and the observation group was supplemented with retention enema with Chaishao Chengqi decoction on the basis of the control group.After treat-ment,the clinical efficacy,relief time of abdominal distension and pain,time of food intake,first time of defecation,recovery time of bowel sound and length of hospital stay of the two groups were compared.Traditional Chinese Medicine(TCM)syn-drome scores,C reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and blood amylase levels before and after treatment were compared between the two groups,as well as the occurrence of adverse reactions between the two groups.Results The total effective rate was 93.33%in the observation group and 73.33%in the control group(P＜0.05).The relief time of abdominal distension and abdominal pain,time of food intake,first time of defecation,recovery time of bowel sound and length of hospital stay in the observation group were shorter than those in the control group(P＜0.01).After treatment,the scores of epigastric distension and pain,sticky stool,fever,chest tightness,dyspeptic and TCM syndrome score in the two groups all decreased,which were lower in the observation group than in the control group(P＜0.05).After treatment,CRP,IL-6,TNF-α and blood amylase in the two groups were decreased,which were lower in the ob-servation group than in the control group(P＜0.05,P＜0.01).There was no significant difference in the incidence of ad-verse reactions between the two groups(P＞0.05).Conclusion Retention enema with Chaishao Chengqi decoction com-bined with external application of Jiuhedan has a good effect on acute pancreatitis with excess heat syndrome of liver and stom-ach,which can effectively reduce the symptoms of patients,promote the recovery of gastrointestinal function,reduce inflam-matory factors and blood amylase levels,and has good safety.
维普
万方数据