Effect of Qingre Jiedu Formula Combined with Fiberoptic Bronchoscope in the Treatment of Refractory Mycoplasma Pneumoniae Pneumonia in Chil-dren with Phlegm-heat Obstructing the Lung Syndrome,and Its Impact on Pulmonary Function,Inflammatory Factors and Im
Objective To explore the effect of Qingre Jiedu formula combined with fiberoptic bronchoscopy on chil-dren with refractory mycoplasmal pneumonia pneumonia(RMPP)with phlegm-heat obstructing the lung syndrome,as well as its impact on pulmonary function,inflammatory factors and immune function.Methods Medical records of 106 children with RMPP admitted from January 2024 to August 2024 were selected.According to different treatment plans,they were divided in-to the observation group(treated with Qingre Jiedu formula combined with fiberoptic bronchoscopy)and the control group(treated with fiberoptic bronchoscopy),with 53 patients in each group.The therapeutic effect and the repair of bronchial mu-cosal injury were evaluated at 2 weeks after treatment in both groups.The pulmonary function indicators,traditional Chinese medicine(TCM)syndrome scores,inflammatory factors,immune function indicators before and at 2 weeks after treatment,and adverse reactions were compared between the two groups.Results At 2 weeks after treatment,the recovery rate of obser-vation group was higher than that of control group(P＜0.05),and the observation group also had a better effect on the repair of bronchial mucosa after treatment than the control group.At 2 weeks after treatment,the maximum expiratory flow rate,forced expiratory volume in one second,and forced vital capacity in both groups increased compared with those before treat-ment,with the observation group showing higher values than the control group(P＜0.05).At 2 weeks after treatment,the scores for cough,fever,yellow phlegm,and asthma in both groups were lower than those before treatment,and the scores for each item in the observation group were lower than those in the control group(P＜0.05,P＜0.01).At 2 weeks after treat-ment,the levels of serum tumor necrosis factor-α,amyloid A/C reactive protein,interleukin-23,and interferon-γ in the ob-servation group decreased compared with those before treatment,which were lower in the observation group than in the control group(P＜0.05,P＜0.01).At 2 weeks after treatment,the levels of CD3+,immunoglobulin A,CD4+/CD8+,and im-munoglobulin G in both groups were higher than those before treatment,and higher in the observation group than in the control group(P＜0.05,P＜0.01).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Qingre Jiedu formula combined with fiberoptic bronchoscopy can inhibit the inflammatory response in RMPP children with phlegm-heat obstructing the lung syndrome,improve clinical symptoms and immune function,enhance pulmonary function,and is safe and effective.
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