Accurate assessment of coronary artery disease severity is crucial for the follow-up diagnosis,treatment,and prognosis of patients with coronary heart disease.As the gold standard for the physiological evalu-ation of coronary artery,fractional flow reserve(FFR)can accurately determine whether coronary artery disease leads to myocardial ischemia.However,FFR operation depends on a pressure guide wire,which is invasive,re-quires drug load,and incurs high costs.Therefore,the clinical use of FFR is limited.Three-dimensional quantita-tive coronary angiography can reconstruct diseased coronary arteries from the original angiography images and cal-culate relevant anatomical parameters of the affected vessels.In recent years,FFR derived from three-dimensional quantitative coronary angiography has also shown application potential in diagnosis,treatment,and prognosis in patients with coronary heart disease.This article will review the research of three-dimensional quantitative coro-nary angiography in coronary heart disease.