Objective:To investigate the electrophysiological alterations after left ventricular assist device(LVAD)implantation for treating end-stage dilated cardiomyopathy.Methods:The clinical data of 16 patients who received LVAD implantation due to end-stage dilated cardiomyopathy in our hospital from May 2018 to March 2023 were retrospectively analyzed.Electrocardiogram examinations were performed before,1 day,and 1 month after LVAD implantation to monitor and evaluate changes in 12-lead electrocardiograms.Results:The absolute QT duration[(412.6±59.6)ms vs(429.8±52.7)ms,P＜0.05],the heart rate-corrected QT interval(QTc)[(491.7±37.2)ms vs(507.8±34.4)ms,P＜0.05]were significantly increased at 1 day post LVAD implanta-tion as compared to before LVAD implantation.However,the QRS duration[(146.6±39.8ms)vs(133.9± 35.3)ms,P＜0.05]was significantly reduced than that before LVAD implantation.With sustained cardiac unloa-ding via LVAD support,there was a marked decrease in the absolute QT duration[(412.6±59.6)ms vs(383.3± 44.4)ms,P＜0.05]and QTc[(507.8±34.4)ms vs(468.7±29.3)ms,P＜0.05]after 1 month of LVAD im-plantation.Conclusion:Electrocardiogram results show that LVAD could effectively reduce left ventricular load,decrease the QRS duration and increase the absolute QT and QTc duration.Delayed decreases in QTc after LVAD implantation may be related to the reversal of electrophysiologic remodeling during the continued unloading period of the heart.
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