Association between visceral fat index and the risk of cardiovascular disease in middle-aged and elderly people in China
杨静芬 1黄晓渝2
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 广东医科大学第一临床医学院(广东湛江,524000)
2. 广东医科大学附属阳江市人民医院心血管内科
折叠
摘要
目的:探究中国人内脏脂肪指数(Chinese visceral adiposity index,CVAI)与中老年心血管疾病发病风险的关联.方法:以2011年中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)的45岁及以上的中老年人信息作为基线数据,并随访至2018年.采用Cox比例风险模型分析不同CVAI水平与心血管疾病发病的关联.结果:研究纳入6 484例基线时无心血管疾病的研究对象,平均年龄为(57.8±9.0)岁.在长达7年的随访期间,心血管疾病的发生率为7.0％.Cox比例风险模型结果表明,在调整潜在的混杂因素后,CVAI每增加1个标准差水平,心血管疾病发病风险增加15％(HR=1.15,95％CI:1.04～1.30),二者存在非线性正相关.亚组分析结果显示,在年龄＞65岁、男性、合并高血压、血脂异常、糖尿病和卒中的人群中,CVAI与心血管疾病发病风险关联不显著.结论:CVAI与中老年心血管疾病发病相关联,在相对年轻的中老年人群的心血管病一级预防中具有应用潜力.
Abstract
Objective:To explore the association between Chinese visceral adiposity index(CVAI)and incident cardiovascular diseases among the Chinese older population.Methods:The baseline data were derived from partici-pants aged 45 years and older in the China Health and Retirement Longitudinal Study(CHARLS)dataset in 2011.Participants were followed up until 2018.Cox proportional models were applied to investigate the association be-tween CVAI and the incidence of cardiovascular diseases.Results:A total of 6 484 participants without prevalent cardiovascular diseases at baseline were included,with a mean age of(57.8±9.0)years.During the 7-ear follow-up period,the incident rate of cardiovascular diseases was 7.0％.After adjusting for potential confounders,the Cox model showed that the risk of cardiovascular diseases increased by 15％(HR=1.15,95％CI:1.04-1.30)per standard deviation increase in CVAI.The association between CVAI and cardiovascular diseases exhibited a non-linear pattern.Subgroup analysis indicated that CVAI was not significantly associated with cardiovascular dis-eases among participants aged older than 65 years or those with hypertension,dyslipidemia,diabetes,and stroke at baseline.Conclusion:CVAI is significantly associated with the incidence of cardiovascular diseases among the Chinese older population,highlighting its potential role in the primary care of cardiovascular diseases,particularly among relatively younger populations.
维普
万方数据