临床心血管病杂志2024，Vol.40Issue(1) ：64-68.DOI:10.13201/j.issn.1001-1439.2024.01.012

高敏感格拉斯哥评分与射血分数保留型心力衰竭患者长期预后的关联性分析

Association between high-sensitivity Glasgow prognostic score and long-term death for acute heart failure with preserved ejection fraction

于炎武 蒲博轩 赫广达 李京阔 雷璐碧 王薇 张丽华
临床心血管病杂志2024，Vol.40Issue(1) ：64-68.DOI:10.13201/j.issn.1001-1439.2024.01.012
✕
  • 维普
  • 万方数据

高敏感格拉斯哥评分与射血分数保留型心力衰竭患者长期预后的关联性分析

Association between high-sensitivity Glasgow prognostic score and long-term death for acute heart failure with preserved ejection fraction

于炎武 1蒲博轩 1赫广达 1李京阔 1雷璐碧 1王薇 1张丽华1
扫码查看

作者信息

  • 1. 中国医学科学院北京协和医学院 国家心血管病中心 阜外医院 国家心血管疾病临床医学研究中心(北京,100037)
  • 折叠

摘要

目的:探索高敏感格拉斯哥评分(high-sensitivity modified Glasgow prognostic score,hs-mGPS)与急性射血分数保留型心力衰竭(heart failure with preserved ejection fraction,HFpEF)住院患者长期预后的关联性.方法:从重大慢病国家注册登记研究心力衰竭前瞻队列中选取HFpEF住院患者,纳入有基线白蛋白和高敏C 反应蛋白(high-sensitivity C-reactive protein,hs-CRP)检测结果的患者,计算其 hs-mGPS 评分.依据 hs-mGPS评分,将所纳入患者分为3组:0分组(hs-CRP≤3 mg/L)、1分组(hs-CRP＞3 mg/L且白蛋白≥35 g/L)、2分组(hs-CRP＞3 mg/L且白蛋白＜35 g/L),探索HFpEF患者的hs-mGPS评分与长期全因死亡及心血管死亡的关联性.结果:共纳入1 575例急性HFpEF患者,中位年龄71(63,79)岁,女性占比50.7％;0分组656例(41.6％),1分组680例(43.2％),2分组239例(15.2％).出院后患者的中位随访时间为4.54(4.09,4.39)年,642例(40.8％)患者发生全因死亡,其中400例(25.4％)发生心血管死亡.多因素Cox分析显示,1分组与2分组患者发生全因死亡风险分别是0分组患者的1.28倍(HR=1.28,95％CI:1.07～1.53,P＜0.01)和2.21倍(HR=2.21,95％CI:1.77～2.76,P＜0.01);此外,2分组患者发生心血管死亡风险是0分组患者的2.32倍(HR=2.32,95％CI:1.75～3.07,P＜0.01).结论:hs-mGPS与急性HFpEF住院患者的长期预后密切相关,其评分越高,出院后全因死亡与心血管死亡风险也越高.

Abstract

Objective:To analyze the relationship between high-sensitivity modified Glasgow prognostic score(hs-mGPS)and long-term death after discharge for heart failure with preserved ejection fraction(HFpEF).Meth-ods:Data were obtained from the patients hospitalized for acute HFpEF in the China Patient-centered Evaluative Assessment of Cardiac Events(PEACE)-Prospective Heart Failure Study.Patients with high-sensitivity C-reac-tive protein(hs-CRP)and albumin data were enrolled in this analysis.Patients were divided into hs-mGPS=0 group(hs-CRP≤3 mg/L),hs-mGPS=1 group(hs-CRP＞3 mg/L and albumin≥35 g/L),hs-mGPS=2 group(hs-CRP＞3 mg/L and albumin＜35 g/L).We analyzed the association between hs-mGPS and risks of long-term all-cause death and cardiovascular death in patients with HFpEF.Results:The study included 1 575 acute HFpEF patients;the median age was 71(63,79)years,and 50.7％were women.There were 656(41.6％)patients in the hs-mGPS=0 group,680(43.2％)in the hs-mGPS=1 group,and 239(15.2％)in the hs-mGPS=2 group.The median follow-up time was 4.54(4.09,4.39)years.A total of 642(40.8％)patients died,among whom 400(24.4％)died for cardiovascular reasons.In multivariable Cox analyses,the risk of all-cause death in the hs-mGPS=1 and hs-mGPS=2 group were 1.28 times(HR=1.28,95％CI:1.07-1.53,P＜0.01)and 2.21 times(HR=2.21,95％CI:1.77-2.76,P＜0.01)than that in the hs-mGPS=0 group.Besides,the risk of cardio-vascular death in the hs-mGPS=2 group was 2.32 times(HR=2.32,95％CI:1.75-3.07,P＜0.01)than that in the hs-mGPS=2 group.Conclusion:hs-mGPS is associated with prognosis in patients with acute HFpEF,and increasing hs-mGPS indicates higher risks of all-cause death and cardiovascular death.

关键词

射血分数保留型心力衰竭/高敏感格拉斯哥评分/死亡/长期预后

Key words

heart failure for preserved ventricular ejection fraction/high-sensitivity modified Glasgow prog-nostic score/risk of death/long term prognosis

引用本文复制引用

基金项目

国家科技部国家重点研发计划(2018YFC1312400)

国家科技部国家重点研发计划(2018YFC1312401)

中国医学科学院医学与健康科技创新工程(2021-12M-1-009)

出版年

2024
临床心血管病杂志
华中科技大学心血管病研究所 华中科技大学协和医院

临床心血管病杂志

CSTPCD
影响因子：0.653
ISSN：1001-1439
参考文献量16
段落导航相关论文