Heart failure(HF)is the final outcome of cardiovascular disease development and the main cause of death in patients with cardiovascular disease.In recent years,with further in-depth research,the treatment of HF is constantly improving.However,the high hospitalization rate and high mortality rate of HF patients are still a major problem,and their quality of life and prognosis are still at a low level.As a soluble guanylate cyclase stimulator,vericiguat provides new ideas for the treatment of HF with its unique mechanism of action,good safe-ty and tolerability,which has great potential.In this paper,we reviewed the pathways,safety and tolerability of vericiguat and the current clinical research progress.