Objective:To investigate the correlation between serum FGF21 concentration and myocardial fibro-sis degree in patients with acute myocardial infarction(AMI),and to explore the effect of FGF21 level on the prog-nosis of patients.Methods:A total of 24 patients diagnosed with AMI(AMI group)and 18 healthy volunteers(control group)were collected.All subjects completed cardiac magnetic resonance examination(CMR),and the third-party software CVI42 was used to analyze the magnetic resonance images,and the left ventricular cardiac function parameters and myocardial fibrosis degree LGE％were analyzed,and the serum FGF21 concentration was measured for statistical analysis.According to serum FGF21 concentration,AMI group was further divided into FGF21 normal group(13 cases)and increased group(11 cases).Clinical data of patients were collected in the inpatient electronic medical record system,and the long-term prognosis of patients was followed up by telephone or outpatient.Adverse cardiovascular events and cardiac ultrasound results were followed up.Results:①The ser-um FGF21 concentration in AMI patients was significantly higher than that in control group(P＜0.05).②Corre-lation analysis results showed that FGF21 concentration was positively correlated with LGE(r=0.763,P＜0.01),LDL(r=0.314,P=0.043),CK-MB(r=0.444,P＜0.01),CK(r=0.455,P=0.026),and HDL(r=-0.423,P=0.026).P＜0.01)had a negative correlation.When the cutoff value of FGF21 in the prediction of myocardial fibrosis was 0.14 ng/ml,the area under ROC curve(AUC)was 0.718,with a sensitivity of 66.7％and a specificity of 77.8％.③The increased group had a significant improvement in LVEF after discharge(P＜0.05).Conclusion:In AMI patients,the concentration of FGF21 is significantly increased,and has a significant positive correlation with the degree of myocardial fibrosis,and the high concentration of FGF21 in the early stage of MI is beneficial to the long-term prognosis of patients.
fibroblast growth factor 21myocardial fibrosiscardiovascular magnetic resonanceacute myo-cardial infarction
NETL
NSTL
万方数据
