Objective:The ratio of tricuspid annular systolic plane excursion(TAPSE)to pulmonary artery systolic pressure(PASP)is an important index for evaluating right ventricle-pulmonary artery coupling.The aim of this study was to evaluate the prognostic value of TAPSE/PASP in elderly patients with heart failure with pre-served ejection fraction(HFpEF).Methods:A total of 466 HFpEF patients aged＞65 years who were hospitalized Fuwai Huazhong Cardiovascular Hospital from December 2017 to July 2021 were retrospectively analyzed.All-cause death and rehospitalization for heart failure were used as the composite endpoint.Follow-up was completed from November 2022 to December 2022.Kaplan-Meier survival analysis curves were used to compare cumulative survival between groups.Cox proportional hazards regression models were used to analyze risk factors for end-point events;and receiver operating characteristic curves(ROC)were used to analyze the predictive value of TAPSE/PASP,TAPSE,and PASP for composite endpoint events.Results:Multivariate Cox regression models showed that TAPSE/PASP≤0.35 mm/mmHg,hyponatremia,blood glucose,and ischemic cardiomyopathy were independent predictors of composite endpoint events in elderly HFPEF patients.ROC curves showed that TAPSE/PASP was superior to TAPSE and PASP alone in predicting all-cause mortality and rehospitalization for heart failure in elderly patients with HFpEF,with AUCs of 0.843(95％CI:0.807-0.879,P＜0.001),0.810(95％CI:0.770-0.849,P＜0.001),and 0.716(95％CI:0.669-0.764,P＜0.001),respectively.Kaplan-Meier survival analysis curves showed that the cumulative survival rate of patients in the TAPSE/PASP≤0.35 mm/mmHg group was significantly lower than that in the TAPSE/PASP＞0.35 mm/mmHg group(P＜0.001).Conclusion:TAPSE/PASP is an independent predictor of all-cause death and heart failure rehospitalization in eld-erly HFpEF patients.The survival rate was higher when TAPSE/PASP＞0.35 mm/mmHg.
right ventricle-pulmonary artery couplingtricuspid annular systolic plane excursionpulmonary artery systolic pressureheart failure with preserved ejection fraction
NETL
NSTL
万方数据
