The treatment of arrhythmia is heavily reliant upon Western medicines.Despite the anti-arrhyth-mic properties,Western medicines also exhibit proarrhythmic effects.Recently,Chinese medicines have emerged as a potential alternative treatment,showing effective antiarrhythmic effects.Most Chinese medicines can directly or indirectly target multiple ion channels and thereby yield favorable outcomes in preventing and treating arrhyth-mias,which have been demonstrated in basic research and clinical trials.Here,we reviewed the electrophysiologi-cal mechanisms and clinical applications of some frequently used Chinese medicines in order to refresh our insights and open up a new perspective and field of vision.