Objective:To investigate the predictive value of blood homocysteine(Hey)and neutrophils counts(ANC)for no-reflow during percutaneous coronary intervention(PCI)in postmenopausal patients with ST-seg-ment elevation myocardial infarction(STEMI).Methods:A total of 126 postmenopausal patients with first-episode STEMI underwent emergency PCI in the General Hospital of Ningxia Medical University from December 2017 to October 2019 were enrolled.According to coronary angiography results,they were divided into the normal flow group(n=95)and the no-reflow group(n=31).Baseline data were compared between the two groups.Logistic regression model was used to analyze the independent factors of no-reflow,and ROC curves were performed to as-sess the predictive efficacy of Hcy and ANC.Results:The incidence of NRP was 24.6％in 126 included patients.After adjusting for confounding factors,logistic regression showed that Hcy(OR=1.136,95％CI:1.067-1.210,P＜0.001)and ANC(OR=1.280,95％CI:1.091-1.501,P=0.002)were independent predictors of no-reflow.ROC analysis showed that the area under the ROC curve(AUC)for predicting myocardial no-reflow by ANC was 0.724(95％CI:0.619-0.829),with a cutoff value of 9.88X109/L,sensitivity of 64.5％,and speci-ficity of 81.1％;The AUC for predicting myocardial no-reflow by HCY was 0.783(95％CI:0.683-0.884),with a cutoff value of 20.04 μmol/L,sensitivity of 67.7％,and specificity of 83.2％;The AUC of Hcy combined with ANC for predicting myocardial no-reflow was 0.838(95％CI:0.753-0.922),with a sensitivity of 90.3％,specificity of 76.3％.Conclusion:Hcy≥20.04 μmol/l and ANC counts≥9.88×109/L can be used to predict the risk of no-reflow during PCI in postmenopausal STEMI patients,and has high predictive value.
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