Here we report a case of a 55-year-old female patient who was admitted to our hospital with"recur-rent chest tightness and shortness of breath for more than a year,aggravated for over half a month",accompanied by hypotension and bilateral lower extremity edema,with echocardiography suggesting diffuse hypertrophy of the left ventricular wall and granular changes of the myocardium.Her diagnosis of mutant transthyretin amyloid car-diomyopathy was finally confirmed by myocardial magnetic resonance,radionuclide bone scintigraphy,endomyo-cardial biopsy,monoclonal immunoglobulin assay,and genetic testing.Six-month follow-up of this patient after taking tafamidis,a specific drug inhibiting transthyretin amyloidosis,showed a slight decrease in myocardial amy-loid deposition on 99Tcm-PYP SPECT/CT imaging and a slight improvement in laboratory tests,but the cycle of acute exacerbations of chronic heart failure occurring in the short term is not significantly shorter.99Tcm-PYP SPECT/CT is an effective tool for early screening and identification of transthyretin amyloidosis.Tafamidis is a potent drug for the treatment of transthyretin amyloid cardiomyopathy.Early screening,diagnosis,and adminis-tration of specific targeted pharmaceuticals will bring a new therapeutic outlook for patients with transthyretin am-yloid cardiomyopathy.
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