Objective:To investigate the dynamic evolution of blood lipids and its influencing factors in patients with rapid progression of coronary artery atherosclerosis.Methods:A total of 201 patients admitted to the Depart-ment of Cardiology,the First Affiliated Hospital of Anhui Medical University from June 2018 to February 2022 who underwent coronary angiography twice within 10(5-12)months were collected.According to the progres-sion of coronary lesions,they were divided into slow progression group(100 cases)and fast progression group(101 cases).The medical history,medication,angiographic features and lipid evolution of the two groups were com-pared,and the influencing factors were analyzed by regression.Results:Compared with the slow progression group,Gensini score increased and stenosis vessels were more as well as the difference of APOA1 decreased in the fast progression group.Multivariate logistic regression analysis showed that the Gensini score(OR=1.020,P=0.000)and APOA1(OR=6.097,P=0.029)were the independent factors in the rapid progression of coronary atherosclerosis.Conclusion:Genisini score and APOA1 reduction are independent factors in the rapid progression of coronary atherosclerotic plaque.
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