Objective:To analyze the roles of thioredoxin interacting protein(TXNIP)and inflammatory body 3(NLRP3)in patients with heart failure(CHF).Methods:The patients were divided into control group(60 ca-ses),ejection fraction retention group(50 cases),intermediate ejection fraction group(50 cases)and reduced ejec-tion fraction group(40 cases).The expression levels of TXNIP,NLRP3 and BNP in plasma were detected.T he results of heart color ultrasound and 6 min walking test were recorded.The TXNIP and NLRP3 in serum were de-tected.Results:During the follow-up period,the expression levels of TXNIP and NLRP3 increased significantly with the decrease of ejection fraction and activity endurance(P＜0.001).Regression analysis showed that TXNIP and NLRP3 were independent risk factors for rehospitalization in patients with heart failure(P＜0.001).The area under curve of TXNIP and NLRP3 in ROC curve were 0.815 and 0.882,respectively.Conclusion:The expression levels of TXNIP and NLRP3 increased with the decrease of ejection fraction and activity tolerance,and TXNIP and NLRP3 could be used as predicators of readmission in patients with heart failure.
heart failurenumber of readmissionsthioredoxin-interacting protein
NETL
NSTL
万方数据
