铁死亡作为动脉粥样硬化治疗靶点最新研究进展
Research progress of ferroptosis as a therapeutic target for atherosclerosis
刘若楠 1王媞 2王大新2
作者信息
- 1. 大连医科大学(辽宁大连,116000);苏北人民医院
- 2. 扬州大学临床医学院附属医院(泰州市人民医院)
- 折叠
摘要
动脉粥样硬化是一类以脂质过氧化沉积导致血管内皮损伤为主要特征的血管慢性炎症性疾病,并且也是引起冠心病、心力衰竭和脑卒中等心脑血管疾病的重要因素.铁死亡是以铁依赖性脂质过氧化物增加为主要特点的一种新型细胞死亡形式,业已证明可以通过不同的信号途径参与动脉粥样硬化的发生和发展.本文结合前期的资料与研究进一步探讨铁死亡的机制及其相关通路在动脉粥样硬化中发挥的作用,以为临床上防治动脉粥样硬化提供更多的科学依据.
Abstract
Atherosclerosis is a chronic vascular inflammatory disease mainly characterized by lipid peroxida-tion deposition causing vascular endothelial damage,and is an important factor in coronary heart disease,heart failure,stroke and other cardiovascular and cerebrovascular diseases.Ferroptosis is a new form of cell death char-acterized by the increase of iron-dependent lipid peroxides,which has been shown to be involved in the occurrence and development of AS through different signaling pathways.In this paper,the mechanism of ferroptosis and its role in atherosclerosis were further discussed.
关键词
动脉粥样硬化/铁死亡/脂质过氧化/细胞死亡Key words
atherosclerosis/ferroptosis/lipid peroxides/cell death引用本文复制引用
基金项目
国家自然科学基金资助项目(82170508)
出版年
2024
NETL
NSTL
万方数据