Clonal hematopoiesis of indeterminate potential:insights about aging,inflammation and atherosclerosis
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潜能未定的克隆性造血(clonal hematopoiesis of indeterminate potential,CHIP)是一种由年龄相关体细胞突变所致、致病潜能未定的造血干细胞扩增.新近研究显示,CHIP与动脉粥样硬化疾病的发生密切相关,CHIP相关突变(如DNMT3A、TET2、JAK2等)可激活炎症相关信号通路(如NLRP3、AIM2炎症小体等),诱发局部炎症反应,促进动脉粥样硬化斑块的形成,对于抗炎药物的开发与应用有重要意义.本文拟从流行病学、分子机制和临床意义3个方面,探讨CHIP与衰老、炎症和动脉粥样硬化发病机制的关系.
Clonal hematopoiesis of indeterminate potential(CHIP)refers to clonal hematopoiesis driven by age-related somatic mutations with undetermined potential for hematologic malignancy.Recent studies suggest that CHIP plays an important role in the pathogenesis of atherosclerosis,as mutations of CHIP genes(e.g.,DN-MT3A,TET2,JAK2)could activate inflammation signal pathways(e.g.,NLRP3,AIM2 inflammasomes),in-duce regional inflammatory response,thereby promoting the formation of atherosclerotic plaques,for which anti-inflammatory medications could be effective and of great interest.The current review aims to discuss the interac-tions between CHIP,aging,inflammation and atherosclerosis from the perspectives of epidemiology,molecular mechanistic and clinical practice.
clonal hematopoiesis of indeterminate potentialatherosclerosisaginginflammation
NETL
NSTL
万方数据
