Neutrophil extracellular traps(NETs)are web-like DNA structures decorated with histones and neutrophil granule proteins in capturing and killing pathogens.During myocardial infarction,an abnormal increase in the level of NETs exacerbates the inflammatory response and tissue damage.The current study suggests that activation of related ion channels may regulate the formation of NETs through different pathways,leading to car-diovascular adverse events such as ventricular remodeling and arrhythmias after myocardial infarction.In this pa-per,we first described the pathways during NETs formation and their role in acute myocardial infarction.We also summarized in detail the role and mechanism of ion channels in NETs formation during acute myocardial infarc-tion,including SK,TRP,P2X,and CFTR on neutrophils,which may provide new ideas for mitigating cardiac re-modeling and arrhythmias after myocardial infarction.
neutrophil extracellular trapsion channelsreactive oxygen species
NETL
NSTL
万方数据
