Fabry disease(FD)is a rare X-linked hereditary disease characterized by lysosomal storage disor-der.FD lesions mainly involved myocardial cells,vascular endothelial cells,smooth muscle cells,renal cells,and neuronal cells.Compared with the normal population,the average life expectancy of FD male patients is reduced by 15-20 years,and the average life expectancy of female patients is reduced by 6-10 years.Cardiovascular system complications are the main cause of death in male(34％)and female(57％)patients.Early detection of cardiac involvement associated with FD and clinical intervention are particularly important.This article reviews the pro-gress of echocardiographic characters of cardiac lesions in FD,which can help in the early detection of cardiac in-volvement.Early comprehensive treatment based on enzyme replacement therapy(ERT)may delay disease pro-gression and improve patient survival.
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