定量血流分数对冠状动脉狭窄诊断效果的meta分析
Diagnostic performance of quantitative flow ratio for coronary artery stenosis:A meta-analysis
黄果 1尚文茹 2隋梦芸 3薛迪4
作者信息
- 1. 北京大学药学院(北京,100091);北京大学医药管理国际研究中心
- 2. 兰州大学基础医学院
- 3. 上海市疾病预防控制中心
- 4. 复旦大学公共卫生学院/国家卫生健康委卫生技术评估重点实验室
- 折叠
摘要
目的:通过meta分析评价基于冠状动脉造影(CAG)的造影剂血流模型定量血流分数(cQFR)对冠状动脉狭窄的诊断效果.方法:通过对6个数据库[PubMed、EMbase、The Cochrane Library、CNKI、万方数据库和中国生物医学文献数据库(CBM)]的检索、文献数据摘录和meta分析(包括meta回归分析),评价cQFR的诊断效果.结果:共纳入32个研究,包括7 209支血管.Meta分析显示,当冠状动脉血管中度狭窄时,cQFR诊断冠状动脉狭窄的总体灵敏度和总体特异度分别为0.86(95％CI 0.82～0.90)和0.91(95％CI 0.88～0.93),总体诊断比值比为60.22(95％CI 43.00～84.34),综合受试者工作特征曲线下面积为0.95(95％CI 0.92～0.96).结论:cQFR对冠状动脉狭窄的诊断效果良好,与血流储备分数相比,其为无创性的检测且费用相对较低,因此具有良好的临床应用前景.
Abstract
Objective:To evaluate the diagnostic performance of contrast-flow quantitative flow ratio(cQFR)for coronary artery stenosis based on coronary arteriography(CAG).Methods:Six database[PubMed,The Co-chrane Library,EMbase,CNKI,WanFang Data and Chinese BioMedical Literature Database(CBM)]search,rel-evant data extraction and Meta analyses(including Meta regression analysis)were conducted to assessing the diag-nostic performance of cQFR in coronary artery stenosis.Results:Totally 35 studies were included with 7 209 ves-sels.Random Meta analyses showed that the pooled sensitivity,pooled specificity,pooled diagnostic odds ratio of cQFR and the area under the summary receiver operating characteristic curve were 0.86(95％CI0.82-0.90),0.91(95％CI0.88-0.93),60.22(95％CI43.00-84.34)and 0.95(95％CI0.92-0.96)when coronary artery stenosis of a branch occupies no more than 80％.Conclusion:cQFR has good diagnostic performance for coronary artery stenosis.Compared to fraction flow reserve(FFR),cQFR is noninvasive and less expensive,and therefore,has good clinical application prospect.
关键词
冠状动脉造影/定量血流分数/冠状动脉狭窄/诊断效果/meta分析Key words
coronary angiography/quantitative flow ratio/coronary artery stenosis/diagnostic performance/meta-analysis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据