Heart failure(HF)is a severe cardiovascular disease with high morbidity and mortality,and cur-rently lacks effective treatment options.Heart failure with preserved ejection fraction(HFpEF)is a common sub-type of HF,characterized by impaired left ventricular diastolic function,with postmenopausal women being the predominant affected population.Fluctuations in estrogen levels are believed to play a significant role in the patho-genesis of HFpEF.This review aims to comprehensively analyze the impact of coronary microvascular disease in-duced by changes in estrogen levels on the development of HFpEF,and provide a foundation for further research on the underlying pathological and physiological mechanisms,as well as the prevention and treatment strategies related to estrogen in HFpEF and microvascular diseases.
heart failure with preserved ejection fractionmicrocirculationestrogenmenopause
维普
万方数据
