Heart failure(HF)is a severe cardiovascular disease with high morbidity and mortality,and cur-rently lacks effective treatment options.Heart failure with preserved ejection fraction(HFpEF)is a common sub-type of HF,characterized by impaired left ventricular diastolic function,with postmenopausal women being the predominant affected population.Fluctuations in estrogen levels are believed to play a significant role in the patho-genesis of HFpEF.This review aims to comprehensively analyze the impact of coronary microvascular disease in-duced by changes in estrogen levels on the development of HFpEF,and provide a foundation for further research on the underlying pathological and physiological mechanisms,as well as the prevention and treatment strategies related to estrogen in HFpEF and microvascular diseases.
关键词
心力衰竭,射血分数保留型/微循环/雌激素/绝经期
Key words
heart failure with preserved ejection fraction/microcirculation/estrogen/menopause
维普
万方数据