Objective:To investigate the relationship between serum Gla-rich protein level(GRP)and the de-gree of coronary artery calcification in patients with unstable angina(UA),and to provide evidence for the diagno-sis and evaluation of coronary artery calcification.Methods:A total of 304 patients diagnosed with UA in the De-partment of Cardiology at Hengshui People's Hospital were selected as subjects.Coronary double-source CT scan was performed,and coronary vascular calcification scores(CACS)were calculated using Agatston correction method.According to CACS,all patients were divided into the non-calcification group(CACS=0,n=78),small-calcification group(1≤CACS≤10,n=48),mild-calcification group(11≤CACS≤100,n=60),moderate-calcification group(101≤CACS≤399,n=68),and severe-calcification group(400≤CACS,n=50).GRP levels in each group were compared.Logistic regression analysis was used to screen the influencing factors of coronary artery calcification,Spearman correlation analysis was used to explore the correlation between serum GRP levels and coronary artery calcification,ROC analysis was used to evaluate the diagnostic value of GRP levels in coronary artery calcification.Results:Generally,the levels of serum GRP decreased gradually with the increase of coronary calcification degree(all P＜0.05).Multivariate logistic regression analysis showed that serum GRP level was an independent protective factor for coronary artery calcification(OR=0.156,95％CI:0.113-0.217,P＜0.05).Spearman correlation analysis showed that serum GRP level was negatively correlated with the degree of coronary artery calcification(r=-0.858,P＜0.05).ROC analysis showed that the area under the curve for predicting coronary artery calcification using GRP was 0.893(95％CI:0.857-0.928),with a cutoff value of 22.68 ng/mL,sensitivity of 72.6％,and specificity of 94.9％.Conclusion:Serum GRP level in UA patients is negatively correlated with the degree of coronary artery calcification.GRP is an independent protective factor for coronary ar-tery calcification and has significant diagnostic value.
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