Objective:To study the effect of mild coronary stenosis on coronary flow reserve(CFR)in patients with chest pain and non-obstructive coronary artery disease.Methods:A retrospective study was conducted in 340 patients with chest pain whose coronary stenosis was less than 50％confirmed by imaging,and the CFR of the left anterior descending branch was measured by the transthoracic Doppler echocardiography under adenosine triphos-phate stress.According to the result of the CFR,the patients were divided into groups with CFR＜2.5(n=84)and CFR≥2.5(n=256).The clinical data,coronary stenosis degree,and echocardiographic parameters were compared between the two groups,and the factors associated with the decrease in CFR were analyzed.Results:Univariate analysis showed that the age,systolic blood pressure,the percentage of female sex,the history of hy-pertension,and the proportion of mild coronary stenosis in the group with CFR＜2.5 were higher than those in the group with CFR≥2.5(all P＜0.05),while BMI,low-density lipoprotein cholesterol(LDL-C),and triglycer-ides(TG)levels in the group with CFR＜2.5 were significantly lower than those in the group with CFR≥2.5(all P＜0.05).Logistic regression analysis showed that coronary artery stenosis(OR=1.995,95％CI:1.060-3.755,P=0.032),age(OR=1.085,95％CI:1.047-1.124,P＜0.01),systolic blood pressure(OR=1.020,95％CI:1.000-1.040,P=0.048)were independently associated with the decrease of CFR.Conclusion:Mild coronary stenosis,age,and systolic blood pressure were independently associated with the decrease of CFR in pa-tients with chest pain and non-obstructive coronary artery disease.
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