Objective:To investigate the relationship between right ventricular function and health-related quality of life(HRQoL)in patients with pulmonary hypertension(PAH).Methods:A total of 319 patients with PAH in the outpatient department were enrolled.The general clinical data,biochemical tests,blood pressure,heart rate,and echocardiography data were collected.Speckle tracking imaging was used to measure the strain of left and right heart,and HRQoL was evaluated by SF-36 scale.Results:In patients with PAH,patients with right ventricular dysfunction(RVD)were older,had longer disease duration,higher NT-proBNP and mean pulmo-nary artery pressure(mPAP).Tricuspid annular plane systolic excursion(TAPSE),fractional area change of right ventricle(RVFAC),tricuspid S',and global longitudinal strain of the right ventricle(RVGLS),as well as total scores for physical and mental health were lower.Stepwise multiple linear regression analysis showed that the du-ration of disease,NT-proBNP,TAPSE,RVGLS,body mass index,mPAP,and age were related to total score for physical health,while the duration of disease,TAPSE,RVGLS,and LVGLS were related to total score for mental health.Conclusion:The quality of life of PAH patients with RVD is worse.The course of disease,TAPSE,and RVGLS are the main risk factors affecting the quality of life.
维普
万方数据
