Objective:To evaluate the correlation between vegetation size and embolism and all-cause mortality in patients with infective endocarditis by meta-analysis.Methods:Relevant trials reported before March 2024 were identified in EMBASE,Pubmed,Elservise and Cochrane.The outcomes included the association of a vegetation size ≥10 mm and＜10 mm with embolic events and all-cause mortality in patients with infective endocarditis.A meta-analysis was conducted after a rigorous literature evaluation using the Newcastle Ottawa scale.Results:Twenty-four studies with a total of 8 873 patients with infective endocarditis were included,of which 7 191 had da-ta on the size of vegetations.The meta-analysis results showed that compared to vegetations＜10 mm,vegeta-tions ≥10 mm significantly increased the incidence of embolic events(OR=2.05,95％CI:1.63-2.56,P＜0.001)and all-cause mortality(OR=1.51,95％CI:1.28-1.78,P＜0.001)in patients with infective endocardi-tis.This correlation became increasingly evident over time.Conclusion:Vegetation ≥10 mm significantly increa-ses the incidence of embolic events and all-cause mortality in patients with infective endocarditis.
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