Objective:To compare the efficacy of PCI combined with different thrombolytic agents in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods:A retrospective study was conducted on 88 STEMI patients who received PCI in Guangdong Second Provincial General Hospital from June 2022 to Au-gust 2023.The patients were divided into recombinant human TNK tissue plasminogen activator for injection group(rhTNK-tPA group,n=25),recombinant human urokinase group(rh-proUK,n=33),and PCI group(control group,n=30)according to treatment strategies.The changes of thrombus grade and the incidence of cardiovascular adverse events in the three groups were compared.Results:rhTNK-tPA has better thrombolysis effect than rh-proUK,and both are better than the control group.There was no difference in adverse cardiovascu-lar events during hospitalization among the three groups.Conclusion:PCI combined with intracoronary thrombol-ysis can better reduce the thrombus load and then better restore myocardial perfusion.Moreover,the thrombolytic effect of rhTNK tPA is better than that of rh proUK.
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