Diuretics are the first-line treatment for acute heart failure and are essential for providing relief from congestion symptoms.However,with advancements in heart failure diagnosis and treatment,diuretic resist-ance has emerged as a significant issue.This resistance can lead to increased rates of hospital readmission and mortality among heart failure patients.The exact mechanism of diuretic resistance is still unclear,posing a chal-lenge in clinical treatment.Recent research has explored potential mechanisms such as intra-abdominal hyperten-sion and pelvic chemoreceptors,leading to the development of corresponding treatment approaches.Additionally,mutations in genes related to organic anion transport polypeptide 2B1 and renal sodium reuptake may provide new avenues for treating diuretic resistance.This article aims to categorize the various mechanisms of diuretic resistance and briefly summarize new treatments for diuretic resistance,enhancing our overall understanding of diuretic resistance.
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