Objective:To analyze the diagnostic value of coronary CT angiography(CTA)in acute coronary syndrome(ACS)and explore the factors affecting the image quality of CTA.Methods:A total of 156 patients with suspected ACS who were treated in our hospital from August 2020 to September 2022 were selected.All patients underwent CTA examination,and coronary angiography(CAG)both.The patients were divided into good image group(116 cases)and poor image group(40 cases),and the influencing factors were analyzed by logistic regres-sion.Results:Among 156 suspected ACS patients,CAG was diagnosed as positive in 106 cases,negative in 50 ca-ses,and CTA was diagnosed as ACS in 104 cases and other 52 cases.The sensitivity of CTA in diagnosing ACS was 88.68%(94/106),specificity was 80.00%(40/50),and accuracy was 85.90%(134/156).There was no sig-nificant difference between the two diagnostic methods in the degree of coronary artery stenosis and the nature of plaque.Compared with the good image group,there were more unsatisfactory breath holding,calcification and ar-rhythmia in the poor image group(P<0.05).Logistic regression analysis showed that unsatisfactory breath hold-ing and calcification were the influencing factors of CTA image quality(P<0.05).Conclusion:CTA has a certain clinical reference value in the diagnosis of ACS.The factors that affect the image quality are unsatisfactory breath holding and calcification.