Objective:To investigate the risk factors of left ventricular thrombosis(LVT)after acute ST-seg-ment elevation myocardial infarction(STEMI)and its influence on hospital prognosis.Methods:A total of 143 a-cute STEMI patients admitted to Jiangsu Province Hospital of Traditional Chinese Medicine from January 2020 to February 2024 were selected and divided into LVT group(23 cases)and non-LVT group(120 cases).Baseline da-ta,clinical indicators,echocardiographic indicators,coronary angiography and major adverse cardiovascular events(MACE)during hospitalization were compared between the two groups.Multivariate logistic regression was used to analyze the independent risk factors for LVT formation in acute STEMI patients.Results:Multivariate logistic regression analysis showed that ventricular aneurysm(OR=3.773,95%CI1.106-12.872,P=0.034),Killip grade≥ Ⅲ(OR=5.914,95%CI1.731-20.202,P=0.005)and LVEF<50%(OR=3.981,95%CI1.178-13.456,P=0.026)were independent risk factors for LVT formation in acute STEMI patients.Compared with the non-LVT group,the incidence of MACE was significantly higher in the LVT group(5.0%vs 34.8%,P<0.001).Conclusion:Ventricular aneurysm,LVEF<50%and Killip grade Ⅲ are independent risk factors for LVT formation in acute STEMI patients.LVT can lead to poor prognosis in STEMI patients.