Objective:To analyze serum progranulin(PGRN),monocyte chemoattractant protein-1(MCP-1)and cell division cycle 42(CDC42)levels were associated with the degree of vascular disease in patients with acute myocardial infarction(AMI)in Xining area.Methods:The 81 patients with AMI hospitalized in the Cardiovascular Department of Qinghai Provincial People's Hospital from July 2022 to December 2023 were collected as the case group,and 80 patients without coronary heart disease were collected as the control group.General data,laborato-ry examination and heart color ultrasound were collected.Serum PGRN,MCP-1 and CDC42 levels were deter-mined by enzyme-linked immunosorbent assay.Multivariate logistic regression was used to analyze the risk factors of AMI.Patients with AMI were subdivided according to Gensini score,number of coronary lesions,and Global Acute Coronary Event Registry(GRACE)score.The correlation between the levels of PGRN,MCP-1,CDC42 and the degree of vascular disease in each subgroup was analyzed.Results:① Compared with the control group,the serum levels of PGRN and MCP-1 in AMI group were increased(P＜0.05),and the level of CDC42 was de-creased(P＜0.05);② There were statistical differences in serum PGRN,MCP-1 and CDC42 in different degrees of coronary artery stenosis(P＜0.05);③ The serum PGRN,MCP-1 and CDC42 were significantly different in different number of coronary vascular lesions(P＜0.05).④ There were no significant differences in serum PGRN,MCP-1 and CDC42 among different GRACE groups.⑤ In AMI group,PGRN and MCP-1 were positive-ly correlated with Gensini score and number of lesions(P＜0.05),but not with GRACE score;In AMI group,CDC42 was negatively correlated with Gensini score and number of lesions(P＜0.05),but not with GRACE score.⑥Logistic regression analysis showed that PGRN and MCP-1 were independent risk factors for AM1(P＜0.05).Conclusion:Serum PGRN and MCP-1 were positively correlated with Gensini score and number of coro-nary lesions,while CDC42 was negatively correlated with Gensini score and number of coronary lesions.PGRN and MCP-1 were independent risk factors for AMI.
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