Objective:To explore the effective prevention strategy of transcatheter aortic valve replacement(TAVR)and summarize the relevant experience.Methods:The perioperative data of TAVR patients in the Sec-ond Hospital of Hebei Medical University from 2016 to 2024 were collected,and the occurrence of coronary artery occlusion events in patients after TAVR was retrospectively analyzed.Results:A total of 385 cases of TAVR were treated,including 321 cases via peripheral approach and 64 cases via apical approach.There were 72 high-risk ca-ses with coronary artery,26 cases received coronary artery protection during the operation(2 cases with"chimney"stent,20 cases with coronary opening stent window opening,and 4 cases with coronary protective guide wire or stent prepositioning),17 cases received J-Valve valve with low coronary risk,and the remaining cases were pre-liminatively excluded by further risk assessment without coronary artery protection or corresponding treatment.Postoperative coronary artery obstruction occurred in 1 case,and the incidence of coronary artery obstruction was 0.3%.Conclusion:Coronary artery occlusion is a very serious complication after transcatheter aortic valve re-placement.Although the overall incidence is not high,it is extremely fatal.For high-risk coronary TAVR cases,prevention is more important than remedy,and detailed preoperative investigation and adequate protection during operation are of great significance.In the perioperative period,reasonable methods and proper strategies can effec-tively reduce the occurrence of TAVR-related coronary artery obstruction events and improve the overall success rate of surgery.