Hypertrophic cardiomyopathy(HCM)is an autosomal dominant inherited cardiomyopathy and the most common cause of sudden cardiac death(SCD)in adults.SCD is also the most severe complication of HCM,with an incidence rate of 0.5％to 2.0％in the adult population in China.Due to hypertrophy of the HCM myo-cardial cells,localized myocardial fibrosis and electrical remodeling occur,which are the main pathological bases for the occurrence of malignant arrhythmias and subsequent SCD.Due to the structural characteristics of HCM it-self,early attention and identification of risk factors for SCD are necessary.In addition to the risk factors recom-mended by guidelines,many other factors are significantly associated with SCD and require comprehensive evalua-tion.Based on the risk factors and assessment results,preventive measures for SCD and the rationality of implant-able cardioverter-defibrillator(ICD)implantation should be evaluated.This article reviews the latest advances in the mechanism,risk factors,and preventive measures of SCD in patients with HCM.
hypertrophic cardiomyopathysudden cardiac deathpathogenesisrisk assessmentventricular septal chemical ablationimplantable cardioverter-defibrillator
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