肌钙蛋白在非心脏疾病中升高的机制和价值
The release mechanisms and clinical significance of elevated cardiac troponin in non-cardiac diseases
孙一博 1杨晴 1蔡瑶瑶 1梁岩1
作者信息
- 1. 中国医学科学院北京协和医学院阜外医院内科重症病区ICU(北京,100037)
- 折叠
摘要
心肌肌钙蛋白(cardiac troponin,cTn)是一种存在于心肌细胞内的特异性标志物.当心肌出现可逆或不可逆性损伤时,cTn被释放入循环.除造成心肌损伤的常见心脏疾病外,临床中也能观察到非心脏疾病患者cTn升高.为能正确理解这种升高的意义,本文在介绍cTn来源、释放方式和清除途径的基础上,着重探讨非心脏疾病中cTn升高的机制及其临床价值.
Abstract
Cardiac troponin(cTn)is a specific biomarker present within myocardial cells.When the myocar-dium undergoes reversible or irreversible damage,cTn is released into circulation.While elevated levels of cTn are commonly associated with cardiac diseases,they can also be observed in patients with non-cardiac conditions.To accurately comprehend the significance of cTn elevation,our review explores the mechanisms and clinical implica-tions of elevated cTn in non-cardiac diseases,building upon the introduction of the origin,release mechanisms,and clearance pathways.
关键词
肌钙蛋白/非心脏疾病/心肌损伤/预后Key words
cardiac troponin/non-cardiac diseases/myocardial injury/prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据