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肌钙蛋白在非心脏疾病中升高的机制和价值

The release mechanisms and clinical significance of elevated cardiac troponin in non-cardiac diseases

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心肌肌钙蛋白(cardiac troponin,cTn)是一种存在于心肌细胞内的特异性标志物.当心肌出现可逆或不可逆性损伤时,cTn被释放入循环.除造成心肌损伤的常见心脏疾病外,临床中也能观察到非心脏疾病患者cTn升高.为能正确理解这种升高的意义,本文在介绍cTn来源、释放方式和清除途径的基础上,着重探讨非心脏疾病中cTn升高的机制及其临床价值.
Cardiac troponin(cTn)is a specific biomarker present within myocardial cells.When the myocar-dium undergoes reversible or irreversible damage,cTn is released into circulation.While elevated levels of cTn are commonly associated with cardiac diseases,they can also be observed in patients with non-cardiac conditions.To accurately comprehend the significance of cTn elevation,our review explores the mechanisms and clinical implica-tions of elevated cTn in non-cardiac diseases,building upon the introduction of the origin,release mechanisms,and clearance pathways.

cardiac troponinnon-cardiac diseasesmyocardial injuryprognosis

孙一博、杨晴、蔡瑶瑶、梁岩

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中国医学科学院北京协和医学院阜外医院内科重症病区ICU(北京,100037)

肌钙蛋白 非心脏疾病 心肌损伤 预后

2024

临床心血管病杂志
华中科技大学心血管病研究所 华中科技大学协和医院

临床心血管病杂志

CSTPCD
影响因子:0.653
ISSN:1001-1439
年,卷(期):2024.40(9)