SII对血流动力学紊乱的稳定型心绞痛患者不良心血管事件的预测作用
The predictive effect of systemic inflammatory index on adverse cardiovascular events in stable angina pectoris patients with hemodynamic disturbances
刘尊腾 1谢骞 1刘芬 2宋宁 1赵倩 1刘畅 1武金龙 1杨毅宁 3李晓梅1
作者信息
- 1. 新疆医科大学第一附属医院心内科(乌鲁木齐,830054)
- 2. 新疆医科大学第一附属医院临床医学研究院;新疆医科大学第一附属医院心血管疾病研究重点实验室
- 3. 新疆医科大学第一附属医院心血管疾病研究重点实验室;新疆医科大学中亚高发病率疾病发病机制防治国家重点实验室;新疆维吾尔自治区人民医院心内科;新疆心血管稳态与再生研究重点实验室
- 折叠
摘要
目的:探究系统免疫炎症指数(SII)对血流动力学紊乱的稳定型心绞痛患者主要不良心血管事件(MACE)的预测作用.方法:连续入选2018年6月-2020年12月因稳定型心绞痛就诊于新疆医科大学第一附属医院心脏中心行血流储备分数(FFR)检查的215例患者,收集患者临床信息及入院检查结果,根据血常规检查计算SII.根据随访期间是否发生MACE,将患者分为MACE组(44例)和非MACE组(171例).根据SII中位数(434),将患者分为低SII组(108例)和高SII组(107例).采用Cox回归分析评估SII对血流动力学紊乱的稳定型心绞痛患者预后的影响.采用Kaplan-Meier法绘制生存曲线,运用log-rank检验比较不同SII水平患者的生存率.结果:与非MACE组比较,MACE组患者SII水平显著升高[393.66(286.42,602.08)vs 473.80(301.40,941.98),P=0.037].多因素Cox回归分析显示,SII与血流紊乱稳定型心绞痛患者MACE独立相关(HR=1.001,95％CI:1.000～1.002,P=0.002).Kaplan-Meier 生存分析表明,高 SII 组患者生存率明显降低(P=0.04).结论:SII是血流动力学紊乱的稳定型心绞痛患者MACE的独立预测因子.
Abstract
Objective:To explore the predictive effect of systemic immune inflammatory index(SII)on major adverse cardiovascular events(MACE)in stable angina pectoris patients with hemodynamic disturbances.Meth-ods:A total of 215 patients who underwent fractional flow reserve(FFR)examination due to stable angina pectoris at the Heart Center of the First Affiliated Hospital of Xinjiang Medical University from June 2018 to December 2020 were selected consecutively.Clinical information and admission examination results were collected,and SII was calculated based on blood routine examination.Patients were divided into the MACE group(n=44)and non-MACE group(n=171)according to whether MACE occurred during the follow-up period.According to the medi-an SII(434),patients were divided into the low-SII group(n=108)and high-SII group(n=107).Cox regression analysis was used to evaluate the effect of SII on the prognosis of stable angina patients with hemodynamic disturb-ances.Kaplan Meier method was used to plot survival curves,and log-rank analysis was used to compare the differences in the survival rate among patients with different SII levels.Results:Compared with the non-MACE group,patients in the MACE group had significantly higher levels of SII[393.66(286.42,602.08)vs 473.80(301.40,941.98),P=0.037].Multivariate Cox regression analysis showed that SII was independently associat-ed with MACE in stable angina pectoris patients with hemodynamic disturbances(HR=1.001,95％CI:1.000-1.002,P=0.002).Kaplan-Meier survival analysis showed that the high-SII group had significantly lower survival rate(P=0.04).Conclusion:SII is an independent predictor of MACE in stable angina pectoris patients with he-modynamic disturbances.
关键词
稳定型心绞痛/系统免疫炎症指数/主要不良心血管事件Key words
stable angina pectoris/systemic inflammatory index/major adverse cardiovascular events引用本文复制引用
基金项目
自治区重点研发计划项目(2022B03022-2)
中央引导地方科技发展专项资金(ZYYD2022C21)
"天山英才"培养计划(2023TSYCLJ0035)
出版年
2024
NETL
NSTL
万方数据