Objective:To explore the predictive effect of systemic immune inflammatory index(SII)on major adverse cardiovascular events(MACE)in stable angina pectoris patients with hemodynamic disturbances.Meth-ods:A total of 215 patients who underwent fractional flow reserve(FFR)examination due to stable angina pectoris at the Heart Center of the First Affiliated Hospital of Xinjiang Medical University from June 2018 to December 2020 were selected consecutively.Clinical information and admission examination results were collected,and SII was calculated based on blood routine examination.Patients were divided into the MACE group(n=44)and non-MACE group(n=171)according to whether MACE occurred during the follow-up period.According to the medi-an SII(434),patients were divided into the low-SII group(n=108)and high-SII group(n=107).Cox regression analysis was used to evaluate the effect of SII on the prognosis of stable angina patients with hemodynamic disturb-ances.Kaplan Meier method was used to plot survival curves,and log-rank analysis was used to compare the differences in the survival rate among patients with different SII levels.Results:Compared with the non-MACE group,patients in the MACE group had significantly higher levels of SII[393.66(286.42,602.08)vs 473.80(301.40,941.98),P=0.037].Multivariate Cox regression analysis showed that SII was independently associat-ed with MACE in stable angina pectoris patients with hemodynamic disturbances(HR=1.001,95％CI:1.000-1.002,P=0.002).Kaplan-Meier survival analysis showed that the high-SII group had significantly lower survival rate(P=0.04).Conclusion:SII is an independent predictor of MACE in stable angina pectoris patients with he-modynamic disturbances.
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