Objective:To analyze the changes in the levels of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),mean platelet volume-to-lymphocyte ratio(MPVLR),and systemic immune-inflam-mation index(SII)in patients with immune checkpoint inhibitors(ICIs)-related myocarditis and to evaluate their diagnostic value for ICIs-related myocarditis.Methods:Twenty-six cancer patients who developed myocarditis due to treatment with ICIs,admitted to the Cancer Hospital Affiliated to Xinjiang Medical University from 2020 to 2023,were selected.General clinical data,complete blood counts,and echocardiography parameters were collect-ed.NLR,PLR,MPVLR,and SII were calculated.Changes in the levels of NLR,PLR,MPVLR,and SII at baseline and during the disease course were analyzed.The diagnostic value of these indices during the disease course in ICIs-related myocarditis was evaluated using ROC curve analysis.Results:Among the 26 patients,19 were male,and 7 were female,with a median onset age of 63 years.Electrocardiogram(ECG)and echocardio-graphy findings varied.During the disease course,the levels of NLR,PLR,MPVLR,and SII were significantly higher compared to baseline(all P＜0.05).The area under the ROC curve(AUC)for diagnosing ICIs-related myocar-ditis using NLR was 0.710,PLR was 0.621,MPVLR was 0.686,and SII was 0.692.Conclusion:NLR,PLR,MPV-LR,and SII may serve as potential biomarkers for the diagnosis of ICIs-related myocarditis.
myocarditisneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiomean platelet volume-to-lymphocyte ratiosystemic immune-inflammatory index
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