摘要
目的:分析免疫检查点抑制剂(ICIs)相关性心肌炎患者中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、平均血小板体积/淋巴细胞比值(MPVLR)和全身免疫炎症指数(SII)水平的变化,同时分析其对ICIs相关性心肌炎的诊断价值.方法:选取新疆医科大学附属肿瘤医院2020-2023年收治的因应用ICIs治疗导致心肌炎的肿瘤患者26例.收集患者的一般临床资料、血常规、超声心动图等指标,进一步计算NLR、PLR、MPVLR和SII;分析患者基线及病程中NLR、PLR、MPVLR、SII水平变化;ROC曲线分析病程中NLR、PLR、MPVLR和SII对ICIs相关性心肌炎的诊断价值.结果:26例患者中男性19例,女性7例,中位发病年龄为63岁.心电图及超声心动图表现多样.病程中NLR、PLR、MPVLR、SII值较基线均显著增高(均P＜0.05).病程中NLR诊断ICIs相关性心肌炎的ROC曲线下面积(AUC)为0.710,PLR为0.621,MPVLR为0.686,SII为0.692.结论:NLR、PLR、MPVLR和SII可作为诊断ICIs相关性心肌炎的潜在标志物.
Abstract
Objective:To analyze the changes in the levels of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),mean platelet volume-to-lymphocyte ratio(MPVLR),and systemic immune-inflam-mation index(SII)in patients with immune checkpoint inhibitors(ICIs)-related myocarditis and to evaluate their diagnostic value for ICIs-related myocarditis.Methods:Twenty-six cancer patients who developed myocarditis due to treatment with ICIs,admitted to the Cancer Hospital Affiliated to Xinjiang Medical University from 2020 to 2023,were selected.General clinical data,complete blood counts,and echocardiography parameters were collect-ed.NLR,PLR,MPVLR,and SII were calculated.Changes in the levels of NLR,PLR,MPVLR,and SII at baseline and during the disease course were analyzed.The diagnostic value of these indices during the disease course in ICIs-related myocarditis was evaluated using ROC curve analysis.Results:Among the 26 patients,19 were male,and 7 were female,with a median onset age of 63 years.Electrocardiogram(ECG)and echocardio-graphy findings varied.During the disease course,the levels of NLR,PLR,MPVLR,and SII were significantly higher compared to baseline(all P＜0.05).The area under the ROC curve(AUC)for diagnosing ICIs-related myocar-ditis using NLR was 0.710,PLR was 0.621,MPVLR was 0.686,and SII was 0.692.Conclusion:NLR,PLR,MPV-LR,and SII may serve as potential biomarkers for the diagnosis of ICIs-related myocarditis.
基金项目
科技创新领军人才项目(2022TSYCLJ0068)
新疆维吾尔自治区自然科学基金(2022D01D76)
NETL
NSTL
万方数据