Objective:To evaluate the therapeutic effect of a new type of shockwave lithotripsy in the treat-ment of severe coronary calcification.Methods:Based on the results of coronary angiography and guidance of int-racavitary imaging,25 patients were divided into the shockwave group(n=15)and control group(n=10).In the shockwave group,OCT was performed in 12 cases and IVUS in 3 cases.In the control group,OCT was per-formed in 6 cases and IVUS in 4 cases.The use of consumables during the operation,surgical exposure time,plaque burden,minimal lumen diameter,minimal lumen area,minimal lumen area inside the stent,and stent ex-pansion rate were compared between the two groups.Major cardiovascular adverse events were recorded after sur-gery and during the 6-month follow-up.Results:In the shockwave group,the amount of consumables use during operation was significantly reduced and the exposure time was significantly shortened[(120.34±7.05)min vs(80.66±6.19)min,P<0.05].The plaque burden,minimum lumen diameter,and minimum lumen area after surgery were significantly improved compared to those before operation in both groups(all P<0.05).Compared with the control group,the minimum lumen area in the stent[(9.23±1.37)mm2 vs(11.89±3.25)mm2,P<0.05]and stent expansion rate[(78.31±3.55)%vs(89.22±2.65)%,P<0.05]improved more significantly in the shockwave group.There was no major cardiovascular adverse events occurred in all patients after surgery and during the 6-month follow-up.Conclusion:It is safe and effective to apply the technique of shockwave balloon catheter in coronary artery severe calcification.