Objective:To investigate the risk factors in patients with coronary aneurysmal dilation(CAE)com-plicated with acute myocardial infarction(AMI).Methods:Retrospective analysis was performed on patients ad-mitted to the cardiovascular Department of Xiangyang Central Hospital from January 2017 to December 2023 who underwent coronary artery angiography,and 170 CAE patients were screened out and divided into CAE group(112 cases)and CAE+AMI group(58 cases)according to whether AMI occurred.The clinical data of the two groups were compared.Spearman correlation analysis and logistic regression analysis were performed.Results:In 170 CAE patients,single-vessel coronary angiomatous dilatation was the most common,and the right coronary artery(RCA)was the most involved(57 vessels,accounting for 33.5%).There were significant differences in smoking history,use rate of antiplatelet drugs,low density lipoprotein cholesterol(LDL-C),myocardial troponin I(cTnI),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),C-reactive protein(CRP),white blood cell count(WBC),neutrophil count(Neu),and neutrophil to lymphocyte ratio(NLR)(P<0.05).Spearman correlation a-nalysis showed that LDL-C,CRP,WBC,Neu were positively correlated with cTnI,CK,and CK-MB.Logistic regression analysis showed that smoking,low utilization rate of antiplatelet drugs,high LDL-C and CRP were risk factors for AMI in CAE patients(P<0.05).Conclusion:Smoking,low utilization rate of antiplatelet drugs,high LDL-C and CRP are risk factors for AMI in CAE patients.